Predictive Intelligence for Pandemic Prevention Phase II (PIPP Phase II Centers Program) (nsf23608) | NSF

Nationwide Science Basis

Directorate for Organic Sciences

Directorate for Laptop and Data Science and Engineering

Directorate for Social, Behavioral and Financial Sciences

Directorate for Mathematical and Bodily Sciences     Division of Mathematical Sciences

Directorate for Engineering     Division of Civil, Mechanical and Manufacturing Innovation

Letter of Intent Due Date(s) (required) (due by 5 p.m. submitter’s native time):

     August 25, 2023

Full Proposal Deadline(s) (due by 5 p.m. submitter’s native time):

     December 08, 2023

IMPORTANT INFORMATION AND REVISION NOTES

Any proposal submitted in response to this solicitation ought to be submitted in accordance with the NSF Proposal & Award Insurance policies & Procedures Information (PAPPG) that’s in impact for the related due date to which the proposal is being submitted. The NSF PAPPG is often revised and it’s the duty of the proposer to make sure that the proposal meets the necessities specified on this solicitation and the relevant model of the PAPPG. Submitting a proposal previous to a specified deadline doesn’t negate this requirement.

SUMMARY OF PROGRAM REQUIREMENTS

Normal Data

Program Title:

Predictive Intelligence for Pandemic Prevention Section II (PIPP Section II Facilities Program)

Synopsis of Program:

Synopsis of Program:

Regardless of a long time of analysis, scientists don’t absolutely perceive the dynamic nature of pathogen and illness emergence. Rising (and re-emerging) pathogens symbolize a unbroken threat to nationwide safety as a result of they threaten well being (animal, human, and ecosystem) and financial stability. Typically, society falls brief on the coordination and breadth of experience wanted to answer such threats. Efficient responses to rising pathogens would require sustained, global-scale efforts of researchers and organizations. This could solely be completed by synergistic integration of revolutionary scientific and technological advances throughout disciplines and scales, and efficient information switch into follow. As a part of these efforts, NSF is organizing a set of actions across the broad theme of Predictive Intelligence for Pandemic Prevention (PIPP).

The PIPP initiative focuses on foundational analysis and improvement actions wanted to sort out grand challenges in infectious illness pandemics by means of prediction and prevention. The PIPP Section II Facilities Program expands upon the Section I Growth Grant Program and is the NSF’s flagship program to determine a community of Facilities or large-scale awards/investments that may help interdisciplinary team-based approaches to speed up analysis and improvement actions in rising infectious ailments and pandemics. The general purpose of the PIPP Section II Facilities program is to help analysis and improvement actions wanted to rework society’s skill to forecast the chance of pandemic-scale occasions, detect outbreaks early, and reply effectively.

Continued development, enabled by sustained federal funding channeled towards problems with nationwide significance holds the potential for additional financial impression and public well being enhancements.

Knowledgeable by visioning actions within the scientific neighborhood in addition to a earlier spherical of improvement grant actions (PIPP Section I), this system invitations proposals for Facilities which have a principal focus in one of many following multidisciplinary themes:

Theme 1: Pre-emergence – Predicting and detecting uncommon occasions in advanced, dynamical methods

Theme 2: Knowledge, AI/ML and Design – Computing, manufacturing and know-how innovation for pandemics

Theme 3: The Host because the Universe – Figuring out host-pathogen tipping factors that dictate management or unfold of an an infection

Theme 4: Human Methods – The function of human habits, actions and environments in illness emergence, transmission, and response or mitigation

These parts instantly help the NSF’s strategic objectives by funding innovative science aimed toward societal challenges and alternatives that face the Nation, whereas concurrently working to develop a globally aggressive and numerous science, engineering and technology-adept workforce.

The Directorates for Organic Sciences (BIO), Laptop Data Science and Engineering (CISE), Engineering (ENG), Social, Behavioral and Financial Sciences (SBE), and Arithmetic and Bodily Sciences (MPS) are collectively collaborating to help the PIPP Section II actions. Involvement of and collaboration with different analysis communities with vital effort in associated areas, together with use-inspired analysis is very inspired.

Cognizant Program Officer(s):

Please word that the next info is present on the time of publishing. See program web site for any updates to the factors of contact.

Katharina Dittmar, phone: (703) 292-7799, e-mail: [email protected]
Mitra Basu, phone: (703) 292-8649, e-mail: [email protected]
Goli Yamini, phone: (703) 292-8910, e-mail: [email protected]
Rebecca Ferrell, phone: (703) 292-7850, e-mail: [email protected]
Zhilan J. Feng, phone: (703) 292-7523, e-mail: [email protected]
Daniel McAdams, phone: (703) 292-4654, e-mail: [email protected]
Joanna Shisler, phone: (703) 292-5368, e-mail: [email protected]
Joseph M. Whitmeyer, phone: (703) 292-7808, e-mail: [email protected]
Catalina Achim, phone: (703) 292-2048, e-mail: [email protected]

Relevant Catalog of Federal Home Help (CFDA) Quantity(s):

47.041 — Engineering
47.049 — Mathematical and Bodily Sciences
47.070 — Laptop and Data Science and Engineering
47.074 — Organic Sciences
47.075 — Social Behavioral and Financial Sciences

Award Data

Anticipated Kind of Award: Cooperative Settlement

Estimated Variety of Awards: 4 to 7

In complete, 4 (4)-7 (seven) awards within the quantity of $15-18M every (complete over 7 years) are anticipated over your entire competitors, topic to the provision of funds and the end result of the proposal overview course of.

Anticipated Funding Quantity: $126,500,000

Estimated program price range, variety of awards and common award dimension/length are topic to the provision of funds.

Eligibility Data

Who Could Submit Proposals:

Proposals could solely be submitted by the next:

Establishments of Greater Schooling (IHEs) – Two- and four-year IHEs (together with neighborhood faculties) accredited in, and having a campus positioned within the US, appearing on behalf of their college members. Particular Directions for Worldwide Department Campuses of US IHEs: If the proposal contains funding to be supplied to a global department campus of a US establishment of upper training (together with by means of use of subawards and marketing consultant preparations), the proposer should clarify the profit(s) to the challenge of efficiency on the worldwide department campus, and justify why the challenge actions can’t be carried out on the US campus.
Non-profit, non-academic organizations: Unbiased museums, observatories, analysis laboratories, skilled societies and comparable organizations positioned within the U.S. which can be instantly related to instructional or analysis actions.

Who Could Function PI:

The Lead PI should be a college member or equal on the lead group. A letter of dedication from the Dean or equal on the lead group should be submitted as a part of the proposal given the broad focus of the facilities.

NOTE: Submission or award of a Growth Grant (PIPP Section I) will not be required to take part within the PIPP Section II Facilities Program competitors.

Restrict on Variety of Proposals per Group: 1

A company could submit no multiple Letter of Intent to this solicitation as lead group. A company could submit as much as one full proposal that corresponds to a Letter of Intent submitted to this solicitation. A full proposal that doesn’t correspond to a Letter of Intent submitted to this system shall be returned with out overview.

Restrict on Variety of Proposals per PI or co-PI: 1

A person could also be designated as PI or co-PI (this does not embody non PI/co-PI senior personnel) on at most one full proposal to this solicitation. Within the occasion that a person exceeds this restrict on the full proposal submission stage, proposals shall be accepted primarily based on earliest date and time of submission, i.e., the primary compliant full proposal shall be accepted, and the rest shall be returned with out overview.

Proposal Preparation and Submission Directions

A. Proposal Preparation Directions

Letters of Intent: Submission of Letters of Intent is required. Please see the total textual content of this solicitation for additional info.

Preliminary Proposal Submission: Not required

Full Proposals:

B. Budgetary Data

C. Due Dates

Letter of Intent Due Date(s) (required) (due by 5 p.m. submitter’s native time):

     August 25, 2023

Full Proposal Deadline(s) (due by 5 p.m. submitter’s native time):

     December 08, 2023

Proposal Evaluation Data Standards

Benefit Evaluation Standards:

Nationwide Science Board permitted standards. Further benefit overview standards apply. Please see the total textual content of this solicitation for additional info.

Award Administration Data

Award Circumstances:

Further award circumstances apply. Please see the total textual content of this solicitation for additional info.

Reporting Necessities:

Further reporting necessities apply. Please see the total textual content of this solicitation for additional info.

TABLE OF CONTENTS

Abstract of Program Necessities

Introduction
Program Description
Award Data
Eligibility Data
Proposal Preparation and Submission Directions
Proposal Preparation Directions
Budgetary Data
Due Dates
Analysis.gov/Grants.gov Necessities

NSF Proposal Processing and Evaluation Procedures
Benefit Evaluation Rules and Standards
Evaluation and Choice Course of

Award Administration Data
Notification of the Award
Award Circumstances
Reporting Necessities

Company Contacts
Different Data

I. INTRODUCTION

Regardless of a long time of analysis, scientists don’t absolutely perceive the dynamic nature of pathogen and illness emergence. Rising (and re-emerging) pathogens symbolize a unbroken threat to nationwide safety as a result of they threaten well being (animal, human, and ecosystem) and financial stability. Typically, society falls brief on the coordination and breadth of experience wanted to answer such threats. Efficient responses to rising pathogens would require sustained, global-scale efforts of researchers and organizations. This could solely be completed by synergistic integration of revolutionary scientific and technological advances throughout disciplines and scales, and efficient information switch into follow. As a part of these efforts, NSF is organizing a set of actions across the broad theme of Predictive Intelligence for Pandemic Prevention (PIPP).

The PIPP initiative focuses on foundational analysis and improvement actions wanted to sort out grand challenges in infectious illness pandemics by means of prediction and prevention. The PIPP Section II Facilities Program expands upon the Section I Growth Grant Program and is the NSF’s flagship program to determine a community of Facilities or large-scale awards/investments that may help interdisciplinary team-based approaches to speed up analysis and improvement actions in rising infectious ailments and pandemics. The general purpose of the PIPP Section II Facilities program is to help analysis and improvement actions wanted to rework society’s skill to forecast the chance of pandemic-scale occasions, detect outbreaks early, and reply effectively.

Every PIPP Section II Heart is envisioned as a catalytic drive that:

Builds a deeper understanding of foundational analysis points which can be important in predictive intelligence for pandemic prevention.
Innovates in a multitude of science and engineering fields inside every theme, together with, however not restricted to: environmental, organic, social, behavioral, financial, mathematical, pc and knowledge science and engineering science.
Supplies use-inspired insights to important issues referring to predictive intelligence for pandemic prevention that speed up translation of analysis outcomes to follow with societal impression.

Profitable Facilities are motivated by clear and compelling foundational and interdisciplinary analysis questions and pursue actions which can be targeted in one among themes under. Whereas every theme has a transparent focus in some disciplines, analysis and improvement actions should draw collectively knowledge, idea, instruments, infrastructure and concepts that cross all related disciplinary boundaries (e.g., environmental, organic, chemical, bodily, supplies, social, behavioral, financial, mathematical, pc and knowledge science and/or engineering science), and replicate this in balanced experience on the staff of collaborators and individuals.

Themes:

Theme 1: Pre-emergence – Predicting and detecting uncommon occasions in advanced, dynamical methods

Theme 2: Knowledge, AI/ML and Design – Computing, manufacturing and know-how innovation for pandemics

Theme 3: The Host because the Universe – Figuring out host-pathogen tipping factors that dictate management or unfold of an an infection

Theme 4: Human Methods – The function of human habits, actions and environments in illness emergence, transmission, and response or mitigation

NSF expects that any new Heart will implement an revolutionary vary of approaches to generate new analysis questions, supporting the conceptualization of novel observations and experimental approaches which can be enabled by cutting-edge technological advances, and growing instructional and coaching actions that may facilitate future pandemic preparedness.

PIPP Section II Facilities are supposed to be nationwide nexus factors for collaborative efforts in pandemic analysis and prevention. We urge broad and artistic desirous about the shape, construction, and actions of those new Facilities, with the mandates that it contains the broadest attainable neighborhood and disseminate outcomes by means of cooperative interactions amongst scientists and society. Participation of different related entities past establishments of upper training is very inspired (e.g., federal companies, trade, non-profits, foundations, museums, and so forth).

Applicable experience should be effectively built-in in an interdisciplinary staff that works throughout scientific, disciplinary, geographic, and organizational divides to implement an efficient convergent strategy to pandemic predictive intelligence and should be effectively justified within the Heart’s imaginative and prescient. To that impact, effectively supported and compelling analysis and administration plans are important, as described in additional element under. These plans ought to be accompanied by clear metrics and milestones required to judge the Heart’s efficiency.

Every profitable PIPP Section II Heart can have interacting preliminary parts that attain past the foundational analysis questions. Mainly, Facilities ought to speed up the transition of improvements into related financial and/or coverage sectors, and nurture and develop the subsequent era of expertise mandatory to answer future pandemic challenges.

Therefore, Heart actions should embody workforce improvement and participation of the total spectrum of numerous expertise in STEM, in any respect participant ranges.

The parts above instantly help the NSF’s strategic objectives by funding innovative science aimed toward societal challenges and alternatives that face the Nation, whereas concurrently working to develop a globally aggressive and numerous science and engineering workforce.

Foundational Analysis and Use-Impressed Insights

Foundational analysis on grand challenges in predictive intelligence for pandemic prevention is the first focus of this program and tasks ought to search to develop or advance idea and strategies which can be impartial of any explicit area of software. Nonetheless, within the context of this solicitation use-inspired, solution-oriented elements of foundational analysis are significantly inspired and will embody analysis parts and broader impacts. The long run purpose of PIPP Section II Facilities is to allow an iterative cycle of co-design and co-creation by groups of researchers, practitioners and customers that catalyze and uncover game-changing applied sciences and options to deal with societal and financial challenges associated to pandemics. A pure extension of this iterative cycle is to advance the Nation’s huge and numerous expertise pool and develop the Nation’s future workforce in epidemic and pandemic preparedness and international well being safety.

II. PROGRAM DESCRIPTION

II. A. Program Imaginative and prescient

The latest COVID-19 pandemic has had devastating results on human well being and livelihoods. Nonetheless, future pandemics could also be considerably totally different. They could be attributable to as but unknown pathogens, have an effect on a broader vary of hosts, or have extra dire impacts on well being or the financial system. Organic pathogens don’t respect borders, they fluctuate tremendously of their properties, together with their replication methods, their hosts, and routes of unfold. Environmental change is more likely to have an effect on the frequency of pandemics, human behaviors, actions and environments have an effect on illness emergence and transmission, and human responses to illness outbreaks additionally fluctuate tremendously.

Therefore, the purpose of this effort is to rework society’s skill to forecast the chance of pandemic-scale occasions, detect outbreaks early, and reply shortly, thereby limiting transmission earlier than an epidemic, not to mention a pandemic, can happen.

The PIPP initiative offers a chance for multidisciplinary groups to work throughout scientific, disciplinary, geographic, and organizational divides to implement an efficient strategy to pandemic predictive intelligence. Crucial to reaching efficient approaches that scale back the chance of recurrence and impression of pandemics is the One Well being framework, which acknowledged the interconnection between individuals, animals (home and wildlife), crops, and the setting. Therefore this program accepts Heart proposals that work in any or throughout a number of organismal methods.

Pandemic preparedness within the context of a One Well being strategy requires foundational analysis on integrating organic information about molecular, mobile, physiological and behavioral properties of organisms and interactions of pathogens, their hosts and the host ecosystems with details about pathogen transmission and evolutionary dynamics, particularly within the face of environmental change. A precedence is strategic identification of genetic or molecular signatures and understanding of host-pathogen-environment interplay mechanisms that can be utilized to find, monitor, decrease or stop rising ailments. Nonetheless, the foundational capabilities wanted to rework this organic information into outbreak prediction and prevention can’t be superior with out convergent and interdisciplinary approaches and technological advances in computing, knowledge assortment, modeling and simulation, distributed sensing know-how and capability, and synthetic intelligence (AI). Therefore, insights and innovation from pc and knowledge science and engineering are important in producing and integrating information for infectious illness pre-emergence, outbreak, prediction and prevention. Moreover, how human attitudes and actions, social habits and human environments and the drivers underlying these contribute to illness transmission, prediction and/or prevention, together with by means of their dedication of coverage and laws, should be thought-about.

II.B. Program Scope

Constructing on visioning workout routines and the PIPP Section I Growth Grant Program, the PIPP Section II program will fund Facilities comprised of scientists, engineers, practitioners, and/or educators united by a typical concentrate on advancing the analysis frontiers of epidemic and pandemic preparedness and nationwide and international well being safety. This system seeks to construct a broad, nationwide set of facilities to pursue transformational advances in a spread of science and engineering fields – see Heart Themes, under. PIPP Section II Facilities can have as their major focus the development of multidisciplinary, multi-stakeholder pandemic analysis on larger-scale, longer-time-horizon challenges than are supported in typical analysis grants.

In opposition to this broad and bold scope, it’s anticipated that every Heart will pursue their imaginative and prescient in methods which can be greatest suited to its chosen analysis focus, amenities, collaborations, and different distinctive circumstances. Proposers are inspired to convey the distinctive qualities of the proposed Heart, whereas addressing the next:

Facilities are coherent multidisciplinary teams of scientists, engineers, practitioners, and/or educators applicable for a large-scale, long-term analysis agenda for the development of pandemic analysis and innovation in software sectors of nationwide significance. The multidisciplinary nature of those Facilities will catalyze coordinated, convergent, and nimble responses to pandemics and pandemic analysis wants that aren’t hindered by silos and lack of shared knowledge. Moreover, the person tasks {that a} Heart could perform ought to meaningfully combine into elementary contributions past the sum of the person tasks.


PIPP Section II Facilities innovate and advance foundational analysis that may have broad and lasting impression, contributing new information or strategies towards understanding the rise, unfold and response to pandemics (see this system imaginative and prescient specified above). Facilities aimed toward advancing established strains of analysis ought to display the potential to radically advance these areas past the state-of-the-art. For Section II Heart proposals that come up from a PIPP Section I Growth grant, proposals are anticipated to deal with how new foundational analysis and improvement priorities arose and superior from earlier funding. PIPP Section II Heart proposals that don’t describe a transparent plan to attain formidable advances in foundational analysis is not going to be aware of this solicitation. It’s important that proposals clearly specify how the use-inspired context for Heart analysis reveals the alternatives for foundational advances and the way these foundational advances in flip contribute to the associated sectors that outline the use-inspired context. This dimension of a center-scale proposal will characteristic clear and compelling objectives to boost the switch of information by means of the significant change of scientific and technical info with exterior stakeholders resembling industrial companions, public coverage makers and customers, or worldwide organizations, in addition to with the broader scientific and academic neighborhood. By way of use-inspired contexts, Facilities have the potential to create and share new neighborhood infrastructure, together with knowledge and software program and/or analytical capability, to additional analysis, promote knowledge and analysis reproducibility, and help training.

PIPP Section II Facilities actively construct the subsequent era of expertise for a various, well-trained workforce. Particularly, a Heart ought to leverage the visionary nature of their analysis foci to drive new and revolutionary training and improvement tailor-made towards e.g., undergraduates, graduate college students, and post-doctoral researchers, in addition to by means of neighborhood faculties and expert technical workforce coaching and different alternatives as applicable that advance information and training of pandemic associated analysis. This might embody revolutionary pedagogy, curricula and tutorial supplies, superior studying applied sciences, project-driven coaching, cross- disciplinary and collaborative analysis, trade partnerships, and new profession pathways. Facilities ought to provide broad, deep, and numerous experiences to construct the subsequent era of a workforce able to take care of pandemic threats, with a concentrate on broadening participation among the many full vary of teams at present under-represented in science and engineering. Facilities ought to maximize their distinctive place to develop the subsequent era of expertise that may present new discoveries and management.

Every Heart shall be comprised of a number of organizations/entities working collectively to create vital new analysis capabilities. NSF seeks to develop new Facilities of pandemic analysis management all through the nation and encourages leveraging current Facilities of excellence as applicable. Facilities are strongly inspired to incorporate organizations that instantly contribute to NSF’s dedication to broadening participation by partaking a various, globally engaged analysis neighborhood, integrating analysis with training and constructing capability, and increasing efforts to incorporate the participation of the total spectrum of numerous expertise in STEM and numerous establishments throughout all geographical areas. Members ought to be meaningfully built-in into a various Heart. Every Heart can have a lead PI with demonstrated imaginative and prescient, expertise, and capability to handle a posh, multi-faceted, and revolutionary enterprise that integrates analysis, training, broadening participation, and information switch. Every Heart can even be staffed with a Managing Director or Mission Supervisor (distinct from the lead PI) and an appropriate Administration Staff to supervise the operations of the Heart.

PIPP Section II Facilities are nexus factors for collaborative efforts. The “nexus level” operate on this program will not be a mere state of being, however fairly an energetic set of priorities, packages, mechanisms, and so forth., whereby a Heart pursues the persevering with development of collaborations with exterior companions to carry collectively individuals, concepts, issues, and technical approaches for optimum impression past the members and the boundaries of the Heart itself. As nexus factors, Facilities have the potential to proceed to attach with new companions with the most effective groups and approaches from establishments of upper training, federal companies, trade, nonprofits/foundations, facilities/institutes, and nationwide networks. As nexus factors, Facilities promote organizational collaborations and linkages inside and between campuses, faculties, and the world past, and additional the Heart’s mission to broaden participation in analysis, training, and information switch actions by means of a community of companions and associates.

II. C. Heart Themes

Constructing on earlier visioning workout routines and funding alternatives by means of the PIPP Section I Developmental Grant effort, on this spherical, proposals are being solicited within the following high-priority areas, described under. The descriptions for every theme are solely supposed to supply a broad, principal focus, they don’t seem to be exhaustive evaluations of respective fields. Additionally, whereas every theme has a transparent middle of gravity in some disciplines, profitable Heart-scale proposals will combine and innovate throughout all related areas of environmental, organic, chemical, bodily, supplies, social, behavioral, financial, mathematical, pc and knowledge science and engineering science, and replicate this in balanced experience on the staff of collaborators and individuals. Full proposal submissions MUST determine as a principal focus one of many themes described under. This principal theme should be mirrored within the Title of the Mission. Nonetheless, the themes under are usually not mutually unique, and it’s anticipated that connectivity exists between themes.

Theme 1: Pre-emergence – Predicting and detecting uncommon occasions in advanced, dynamical Methods

Pure and social methods are dynamic, stochastic, nonlinear, multi-scale and complicated, making each the theoretical prediction and modeling of its states difficult. Some examples in a predictive context embody: epidemiological transitions from a pre-emergence stage to localized emergence (epidemic) and/or a pandemic; transition of a person or a neighborhood from proof against vulnerable to illness; transition of a microbe from innocent to pathogenic.

Normally, these methods spend protracted durations of time in numerous metastable states and solely very not often, and at seemingly random occasions, transition to different states, usually producing results that cross spatial and organismal scales within the course of. Predicting the dynamics of such methods throughout scales requires the event of frameworks of contextual predictive intelligence to grasp how transition paths work together with a collection of extra and sometimes seemingly unrelated occasions and/or dynamic variables.

One problem to innovation in data-driven and contextual predictive intelligence for pandemics is the necessity to develop Synthetic Intelligence (AI)- and machine studying (ML)-based computational approaches that meaningfully analyze a number of organic knowledge factors (e.g., from bio-surveillance, host-pathogen interactions, at scale ecology) to well timed (real-time, just-in-time) determine occasions which can be biologically related and vital for pandemics. It will require strong mathematical and bodily fashions, and new biologically-cognizant computational approaches to (1) detect and analyze knowledge which can be being collected repeatedly and throughout scales, and (2) determine the important thing occasions (which can seem unrelated on the onset) that precede pandemics. One other, associated problem is the mixing of data-driven approaches with mechanistic fashions to facilitate our understanding of the organic underpinnings of the advanced technique of emergence. It will require integrating molecular to environmental scale knowledge and fashions, with novel computational methods to determine organic, environmental, and/or sociological drivers of uncommon occasions and transition states that affect emergence.

Theme 2: Knowledge, AI/Machine Studying and Design – Computing, sensing, manufacturing and know-how innovation for pandemics

With the present and rising challenges of elevated spill-over threat of pathogens it can be crucial {that a} paradigm shift happens in how pathogens and ailments are recognized throughout ecosystems and hosts in both actual time, or occasions effectively forward of outbreaks (see Theme 1 above). This shift includes bettering the granularity and timeliness of obtainable epidemiological info, with hybrid methods augmenting fairly than supplanting conventional surveillance methods. On the info assortment and knowledge integration area, most obtainable applied sciences are designed for people. Transfer in the direction of new concepts to develop strategies and units grounded in advances of wi-fi applied sciences, computing software program and {hardware}, algorithms, and machine studying that allow knowledge monitoring, acquisition, and evaluation for animal hosts and people is warranted. We envision that info gained on adjustments in animal habits and welfare, physiology, or vary to intelligently and well timed determine pre-pandemic circumstances.

One other important space of analysis to boost prediction is in computational algorithms and frameworks for processing, analyzing, and modeling knowledge to allow inference of difficult-to-measure info and integration of conventional computing and organic computing platforms. This highlights the trouble wanted to attach measurable with troublesome/unmeasurable (observable versus unobservable) organic occasions/traits/processes for pre-emergence forecasting of pandemics. Progress in organic sensor applied sciences, in-situ sensors, and good sensor networks to file difficult-to-measure or monitor in close to actual time mobile and molecular-scale results in addition to to observe organic methods in any respect scales is important. Monitoring methods at the next stage for efficient and complete illness emergence and unfold prediction/evaluation may gain advantage from coordinated options of in-situ detection, computation, and determination by networked sensors, actuators and processors, and bodily processes, along with cybersystems (such ecosystems could possibly be modeled as cyber-physical methods) of simulated occasions the place the interactions between ranges and methods may be simulated to boost, perceive, and generate empirically primarily based coverage. An necessary problem and alternative to advance on this discipline requires a steady and iterative suggestions loop between simulated and actual worlds, which should occur in both actual time or at related time scales.

The event and strengthening of computational strategies and course of of knowledge assortment, evaluation, storage, curation, and analytics, together with a “mannequin commons” serving as a repository of modern modeling and simulation about pathogens and pandemic illness is the idea for a profitable predictive intelligence for pandemic prevention program. However, the growing variety of obtainable fashions and the shortage of greatest practices in coordination, integration and knowledge sharing are main roadblocks within the improvement of the sphere. This solicitation requires a clearly rationalized analysis plan that addresses these issues in any respect steps within the design of computing and networked methods/infrastructure for predictive intelligence for pandemic prevention.

Theme 3: The Host because the Universe – Figuring out host-pathogen tipping factors that dictate management or unfold of an an infection

The host may be the bottleneck or the amplifier of a pathogen. The end result of an infection could change within the face of pathogen mutation and/or adjustments within the host setting. A concerted analysis effort spanning a number of analysis areas is required to grasp the idea for host management within the unfold of an an infection beneath these altering circumstances. Analysis submitted beneath this theme is predicted to pursue important elements of molecular, mobile and physiological mechanisms that dictate the end result of host-pathogen interactions, together with illness outbreaks. This foundational information could possibly be exploited to tell insights to regulate or predict pathogen emergence, determine new therapeutics or vaccines, or predict and perceive the emergence and upkeep of antimicrobial resistance.

A game-changer in pandemic prevention can be distant sensors that autonomously monitor and report on pathogens and their hosts in situ over time and area. Distant instruments and applied sciences for detecting and monitoring adjustments in organic methods and processes which can be additionally able to analyzing and transmitting info from hosts may make attainable the invention of potential for outbreaks previous to society-scale dissemination. Though genome sequencing is now ubiquitous it stays troublesome to make use of this sequence (or different -omics primarily based strategies) to precisely predict hosts for a brand new pathogen, or to detect transmission and amplification routes of a brand new pathogen. This problem could possibly be overcome by advances in engineering and in computational algorithms and frameworks for processing, analyzing and modeling knowledge.

Molecular-level info exists about host responses to an infection and in regards to the bio-synthetic pathways required for a pathogen to outlive in a selected host. This info may be leveraged to develop therapeutic and diagnostic instruments. There may be nonetheless a spot in understanding how these features happen temporally and in live performance throughout the whole host organism, and the hierarchy of mechanisms that lead to management or unfold of an an infection inside a person and all through homo- and heterogeneous hosts. A chance to advance on this discipline is growing mathematical and computational fashions that precisely predict an infection outcomes from sub-cellular occasions.

Theme 4: Human Methods – The function of human habits, actions and setting in illness emergence, transmission, response and mitigation.

The devastating human, financial, and social prices of the latest pandemic have highlighted the pressing want for coordinated analysis and actions to construct resilient methods for pandemic prevention, preparedness, and response. Central to the event of resilient methods is a recognition of the function that people and their environments play in illness and pandemic dynamics and an understanding of the advanced habits of people at particular person, group, organizational, societal, and international scales.

For the aim of this solicitation, the time period setting is broadly construed, it could embody organic, bodily and chemical parts, and will take into account a continuum of environments from these with very restricted human populations (e.g., “pure” environments) to these through which human methods and processes absolutely dominate (e.g. cities, constructed environments). Analysis that meaningfully incorporates social and behavioral processes in epidemiological fashions related to human methods and environments is especially important.

Heart tasks submitted to this theme will due to this fact advance science and engineering analysis on human methods which can be related to improved pandemic prevention and resilience. It’s anticipated that analysis on this theme shall be essentially interdisciplinary and discover elements of how human cognition, habits and attitudes, and the sociocultural and socio-environmental drivers underlying these, contribute to illness emergence, transmission and mitigation. Analysis beneath this theme should tackle human habits and/or social processes, and tasks could, however needn’t, concentrate on human pathogens or human hosts. Understanding the human impression can even permit for the event and optimization of excessive impression strategies for illness surveillance/prevention/suppression/containment/mitigation protocols. Examples of broad areas of focus that leverage and advance foundational analysis in science and engineering and help use-inspired objectives embody, however are usually not restricted to: investigating how the setting and/or human attitudes, beliefs, choices, and exercise patterns contribute to illness transmission and have an effect on pandemic resilience and responses; understanding the processes in water, soil, and/or air that set off or amplify pathogen unfold in human environments; understanding the function of organizations and policymakers in speaking illness threat, coordinating throughout stakeholders, shaping analysis efforts, and planning and implementing illness mitigation protocols; and using and advancing sociocultural and financial fashions and theories in regards to the moral and logistical trade-offs between human well being/privateness and financial/societal well being in an effort to optimize illness prevention and mitigation methods.

II.D. Webinar

NSF will maintain an informational webinar quickly after the discharge of the solicitation and submit the date and registration info for this webinar on the Program Internet web page.

III. AWARD INFORMATION

Anticipated Kind of Award: Cooperative Settlement

Estimated Variety of Awards: 4 – 7

In complete, 4 (4)-7 (seven) awards within the quantity of $15-18M every (complete over 7 years) are anticipated over your entire competitors, topic to the provision of funds and the end result of the proposal overview course of.

Anticipated Funding Quantity: $126,500,000

Estimated program price range, variety of awards and common award dimension/length are topic to the provision of funds.

IV. ELIGIBILITY INFORMATION

Who Could Submit Proposals:

Proposals could solely be submitted by the next:

Establishments of Greater Schooling (IHEs) – Two- and four-year IHEs (together with neighborhood faculties) accredited in, and having a campus positioned within the US, appearing on behalf of their college members. Particular Directions for Worldwide Department Campuses of US IHEs: If the proposal contains funding to be supplied to a global department campus of a US establishment of upper training (together with by means of use of subawards and marketing consultant preparations), the proposer should clarify the profit(s) to the challenge of efficiency on the worldwide department campus, and justify why the challenge actions can’t be carried out on the US campus.
Non-profit, non-academic organizations: Unbiased museums, observatories, analysis laboratories, skilled societies and comparable organizations positioned within the U.S. which can be instantly related to instructional or analysis actions.

Who Could Function PI:

The Lead PI should be a college member or equal on the lead group. A letter of dedication from the Dean or equal on the lead group should be submitted as a part of the proposal given the broad focus of the facilities.

NOTE: Submission or award of a Growth Grant (PIPP Section I) will not be required to take part within the PIPP Section II Facilities Program competitors.

Restrict on Variety of Proposals per Group: 1

A company could submit no multiple Letter of Intent to this solicitation as lead group. A company could submit as much as one full proposal that corresponds to a Letter of Intent submitted to this solicitation. A full proposal that doesn’t correspond to a Letter of Intent submitted to this system shall be returned with out overview.

Restrict on Variety of Proposals per PI or co-PI: 1

A person could also be designated as PI or co-PI (this does not embody non PI/co-PI senior personnel) on at most one full proposal to this solicitation. Within the occasion that a person exceeds this restrict on the full proposal submission stage, proposals shall be accepted primarily based on earliest date and time of submission, i.e., the primary compliant full proposal shall be accepted, and the rest shall be returned with out overview.

Further Eligibility Information:

Minority Serving Establishments (MSIs) are inspired to submit proposals. (Minority Serving Establishments as listed and outlined by the US Division of Schooling record of MSIs: https://www2.ed.gov/about/places of work/record/ocr/edlite-minorityinst.html)

Eligible organizations in EPSCoR jurisdictions are inspired to submit proposals. (EPSCoR Jurisdiction web sites as per NSF: https://new.nsf.gov/funding/initiatives/epscor/state-websites)

Federal companies and federally funded analysis and improvement facilities (FFRDCs) can solely take part as subawardees.

If a proposal includes a number of organizations, it should be submitted as a single proposal with subawards: individually submitted collaborative proposals are usually not permitted and shall be returned with out overview.

V. PROPOSAL PREPARATION AND SUBMISSION INSTRUCTIONS

A. Proposal Preparation Directions

Letters of Intent (required):

Letters of Intent (LOI) are required and should be submitted through Analysis.gov, even when full proposals shall be submitted through Grants.gov.

NOTE: Submission or award of a Growth Grant (PIPP Section I) will not be required to take part within the PIPP Section II Facilities Program competitors.

The Letters of Intent shall be used for planning the overview of proposals. If a corporation submits a Letter of Intent by the deadline then the group is robotically eligible to submit the total proposal; there isn’t a formal invitation or different discover after the Letter of Intent has been submitted. No suggestions shall be given on particular person Letters of Intent, however this system could share common points/reminders through coordinated message to all potential submitters after the submission deadline of the LOI, and previous to full proposal submission.

As a multi-organization exercise, a single, built-in Letter of Intent should be submitted by the lead group; details about different taking part organizations, companions, and senior personnel could also be given in part 4 “Record of Senior Mission Personnel and Taking part Organizations” as described under.

Required parts of the Letter of Intent are given under. It’s the submitting group’s duty to make sure that the Letter of Intent is compliant with all relevant necessities.

The Letter of Intent should include the weather under. Letters of Intent DO NOT need to specify a Theme, however are inspired to take action within the Title. No different sections are permitted.

The Letter of Intent should embody this info:

1. Mission Title

Proposal titles should point out the PIPP Section II program, adopted by a colon, then the title of the challenge (“PIPP Section II: Theme n (the place n is the theme quantity, if identified): Title”). The title ought to describe the challenge in concise, informative language that’s comprehensible to a technically literate reader.

2. Mission Data

i) Synopsis (2500 characters): The Synopsis ought to define the particular objectives of the Heart and spotlight revolutionary elements of the work and the importance of potential outcomes within the discipline of predictive intelligence for pandemic prevention.

ii) Different Feedback (2500 characters): Clarify how the challenge will tackle the Further Solicitation Particular Standards recognized within the Solicitation (Part VI.A.).

3. Non-obligatory Knowledge Fields

iii) Analysis Disciplines (255 characters)

Determine the disciplines through which the analysis is grounded.

iv) Key References (255 characters)

Embody DOI and/or ISBN for key references cited within the Letter of Intent (if relevant).

4. Record of PI/coPIs and different Senior Mission Personnel and Taking part Organizations

v) Embody PI/coPIs and different Senior Mission Personnel and Taking part Organizations

Letter of Intent Preparation Directions:

When submitting a Letter of Intent by means of Analysis.gov in response to this Program Solicitation please word the circumstances outlined under:

Submission by an Approved Organizational Consultant (AOR) is required when submitting Letters of Intent.
A Minimal of 0 and Most of 4 Different Senior Mission Personnel are permitted
A Minimal of 0 and Most of 10 Different Taking part Organizations are permitted
Analysis Disciplines is required when submitting Letters of Intent
Key References is required when submitting Letters of Intent
Submission of a number of Letters of Intent will not be permitted

Full Proposal Preparation Directions: Proposers could decide to submit proposals in response to this Program Solicitation through Analysis.gov or Grants.gov.

Full Proposals submitted through Analysis.gov: Proposals submitted in response to this program solicitation ought to be ready and submitted in accordance with the overall tips contained within the NSF Proposal and Award Insurance policies and Procedures Information (PAPPG). The whole textual content of the PAPPG is accessible electronically on the NSF web site at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg. Paper copies of the PAPPG could also be obtained from the NSF Publications Clearinghouse, phone (703) 292-8134 or by e-mail from [email protected]. The Put together New Proposal setup will immediate you for this system solicitation quantity.

Full proposals submitted through Grants.gov: Proposals submitted in response to this program solicitation through Grants.gov ought to be ready and submitted in accordance with the NSF Grants.gov Software Information: A Information for the Preparation and Submission of NSF Functions through Grants.gov. The whole textual content of the NSF Grants.gov Software Information is accessible on the Grants.gov web site and on the NSF web site at: (https://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide). To acquire copies of the Software Information and Software Types Package deal, click on on the Apply tab on the Grants.gov website, then click on on the Apply Step 1: Obtain a Grant Software Package deal and Software Directions hyperlink and enter the funding alternative quantity, (this system solicitation quantity with out the NSF prefix) and press the Obtain Package deal button. Paper copies of the Grants.gov Software Information additionally could also be obtained from the NSF Publications Clearinghouse, phone (703) 292-8134 or by e-mail from [email protected].

See PAPPG Chapter II.D.2 for steerage on the required sections of a full analysis proposal submitted to NSF. Please word that the proposal preparation directions supplied on this program solicitation could deviate from the PAPPG directions.

Necessary Directions: Full proposals shall be accepted provided that they’re primarily based on a Letter of Intent submitted to this program. As a result of complexity of the proposals being submitted, submitters are strongly inspired to organize and submit proposals with sufficient lead time to resolve potential compliance associated points upfront of the deadline. When making ready a full proposal for this competitors, proposers are suggested to overview the Program Description and the Proposal Evaluation Data discovered on this solicitation for common info pertinent to this program.

As a multi-organization exercise, the proposal should be submitted as a single, built-in proposal by the lead group, with proposed subawards to the opposite associate organizations. Linked collaborative proposals from a number of organizations shall be returned with out overview.

1. Cowl Sheet

TITLE: The title of the proposal should be preceded by “PIPP Section II: Theme n: “, the place n is the theme quantity that’s the major theme to which you might be submitting. The title ought to describe the challenge in concise, informative language that’s broadly comprehensible.

Twin Use Analysis of Concern (DURC) and enhanced Potential Pandemic Pathogens (enhanced PPP): NSF’s present Proposal and Award Insurance policies and Procedures Information (PAPPG, NSF 23-1) incorporates an replace to the company’s coverage on twin use analysis of concern (DURC) (i.e., analysis that makes use of one among 15 choose brokers, produces one among 7 results, and has the potential to be misused).

NSF is dedicated to preserving the advantages of life sciences analysis whereas minimizing the chance of misuse of the information, info, merchandise, or applied sciences supplied by such analysis. Analysis aligned with PIPP Section II themes has the potential to lead to actions or outcomes that will fall inside federal DURC or enhanced Potential Pandemic Pathogen (enhanced PPP) coverage and tips.

NSF nonetheless prohibits funding DURC, however permits for analysis that would create enhanced potential pandemic pathogens (enhanced PPPs) if the advantages of the analysis far outweigh the dangers. Proposing group are actually required to determine submissions proposing any DURC or work with enhanced PPPs by checking a field on the proposal cowl pages labeled “Potential Life Sciences Twin Analysis of Concern.”

Extra info may be present in Chapter II.E.6 and Chapter XI.B.5 of the PAPPG.

2. Mission Abstract (1-page restrict) The Mission Abstract consists of an outline, a press release on the mental benefit of the proposed exercise, and a press release on the broader impacts of the proposed exercise. Embody an outline of the Heart description and rationale, its analysis aims, training and workforce improvement actions, and neighborhood constructing actions. Proposals could incorporate a Key phrases part because the final line of the Mission Abstract, which can be used to spotlight any particular emphasis in sectors related to the theme, or to determine relevance to themes aside from the one to which the proposal is submitted.

3. Mission Description The Mission Description should embody the sections described under and should not exceed 25 pages together with tables and illustrations. Along with these and different PAPPG necessities, the Mission Description for a PIPP Section II proposal should embody the next clearly-labeled sections.

Deviations from the PAPPG:

Chances are you’ll omit the PAPPG-required part, “Outcomes from Prior NSF Assist”. If omitted from the Mission Description, the required info should be submitted, if relevant, as a supplementary doc (described under).

3.a. Overview and Rationale for Heart Strategy: Present a rationale for the principal theme that was recognized, and an outline of the significance of particular elements of the grand problem that the Heart aspires to resolve. Embody timeliness of addressing this problem. Talk about why the PIPP Section II Facilities program is especially suited to help this effort. Talk about the long-term strategic objectives and potential impression of a Heart.

3.b. Description of the Analysis Plan of the Heart: State the general imaginative and prescient and long-range analysis objectives of the Heart. Describe the proposed analysis areas (within the context of the theme), how this plan synergistically advances foundational analysis and use-inspired insights in predictive intelligence for pandemic prevention and the way these efforts shall be built-in in service of the Heart’s analysis imaginative and prescient. Clearly specify the areas of foundational analysis and improvement actions through which vital new information or strategies will contribute to society’s skill to forecast the chance of pandemic-scale occasions, detect outbreaks early, and/or reply shortly; why these actions are chosen; and the Heart’s distinctive capabilities to advance and disseminate these outcomes to the broader neighborhood (together with practitioners, educators or customers). Convey how these advances profit from and contribute to the associated sectors within the chosen use-inspired and translational context. Determine key contributors to those analysis and improvement actions and display their suitability to drive and disseminate the pandemic analysis advances and related disciplines/sectors. Present a seven-year timeline for all actions. Point out the particular function of every associate group or participant in every analysis matter/purpose space. The analysis plan ought to present enough element to permit evaluation of the scientific benefit and to justify the need for the proposed mode of operation. If relevant, clarify how the proposed analysis pertains to different current analysis capabilities (e.g., associated facilities, institutes, amenities and/or nationwide laboratories) in addition to worldwide packages within the proposed fields of analysis. If the Heart plans embody the event of shared analysis amenities, describe plans to construct, handle, and maintain such amenities.

3.c. Broader Impacts: The Mission Description should comprise, as a separate part throughout the narrative, a bit labeled, “Broader Impacts”. Please word that this heading should be by itself line with no different textual content on that line. This part ought to embody, at a minimal, the next three subsections.

3.c.1. Schooling and Workforce Growth: With the purpose of advancing information and training associated to the detection, prediction and response to pandemics, current plans to actively construct the subsequent era of expertise for a various well-trained workforce by means of new and revolutionary approaches to training and workforce improvement. Members could embody undergraduate, graduate college students or post-doctoral researchers, neighborhood faculties, expert technical workforce, K12 college students, and/or professionals trying to shift profession focus. Describe plans for the mentoring {and professional} improvement of individuals concerned in Heart actions. Describe how the Heart will combine analysis and training. Describe all proposed actions in enough element to permit evaluation of their intrinsic benefit, potential effectiveness, and their anticipated contribution towards a extremely competent new era of the US workforce capable of assist predict, stop or mitigate pandemics. Plans may additionally embody mechanisms to have interaction individuals in casual settings (e.g., museums, nature facilities, libraries; TV/movie; citizen science; and different on-line experiences).

3.c.2. Broadening Participation Plans: Describe the broadening participation aims and description evidence- primarily based methods for reaching them, primarily based on related literature. Describe plans for growing range together with the participation of the total spectrum of numerous expertise in STEM in any respect organizational ranges of Heart actions, and cite the related literature on efficient practices. Describe the contribution/function of associate organizations within the broadening participation plans. Clarify why these organizations have been chosen and what they’ll contribute to the challenge. Point out the function of scholars and college from these organizations and the way they are going to be absolutely built-in and engaged into Heart actions. Clarify how progress shall be measured and the way methods shall be tailored, if mandatory. Describe the proposed actions in enough element to permit evaluation of their intrinsic benefit and potential effectiveness.

3.c.3. Collaboration and Data Switch: Describe how the Heart will operate as a nexus level for collaborative efforts, together with plans to hyperlink organizations, individuals, concepts, issues, and technical approaches for optimum impression. Current plans to combine associate organizations and individuals into a various Heart that’s extra than simply the sum of its elements. Embody right here plans to impact information switch. Data switch includes the change of scientific and technical info between the Heart and exterior non-academic stakeholders (resembling industrial companions or public policy-makers) with the target of making use of that information. State the particular objectives for information switch and the anticipated impression of the actions. Linkages ought to contain vital mental change and will contain, for instance, mechanisms resembling internships or novel use of cyberinfrastructure to boost connections.

3.d. Key Personnel, Administration and Integration Plan: Describe the multidisciplinary group of scientists, engineers, practitioners and/or educators comprising the Heart and their suitability to conduct large-scale, long-term analysis agenda to advance innovation in analysis and software sectors of predictive intelligence for pandemic prevention. Describe the community of organizations comprising the Heart and their relationships to at least one one other. Embody a diagram to elucidate the organizational relationships and reporting construction among the many key areas of duty. Describe the particular roles of the Heart Administration Staff, the timeline for hiring of key personnel and areas of duty, together with within the day-to-day administration and operations of the Heart. Describe the related expertise and desired {qualifications} of the Heart Director, Mission Supervisor (each required, and distinct from PI), and different key members of the administration staff to guide and handle a posh, multi-faceted, and revolutionary enterprise that integrates analysis, training, broadening participation, and information switch (see under for additional description). Describe the processes for use to prioritize Heart actions; to pick and combine analysis tasks with each other and with different Heart actions; to determine and sundown tasks that stop to align with Heart objectives; to allocate funds and tools throughout Heart actions and amongst companions; to resolve battle; and to pick a alternative for key leaders if wanted.

Key Personnel, Specifics:

Heart Director (required): NSF views the Director as important to profitable operation of the Heart. Subsequently, the scientific management and administration {qualifications} of the Director are important to a profitable proposal. The Director ought to be liable for administration and staffing; applicable Heart oversight, together with guaranteeing an inclusive and equitable local weather that shall be welcoming to numerous scientists; efficient communication with the broad analysis neighborhood, different applicable organizations, and most of the people; and administration of the funds supplied. The Principal Investigator of a proposal is predicted to be the Heart’s Director or Interim Director; if the latter, the proposal should clearly describe the method that shall be used to pick a Director.

Mission Supervisor (required) – It’s anticipated that the Heart can have a Mission Supervisor (or Affiliate Director) with applicable project-management coaching whose duties typically embody challenge execution planning, procuring and managing challenge assets, scheduling, assessing dangers and alternatives, and guaranteeing that milestones and outcomes are being met and budgets balanced. This particular person ought to be designated as senior personnel within the proposal. We strongly discourage post-doctoral researchers to be positioned into this place.

Different Key Positions: The Heart would require full-time employees positions to foster excellence in areas resembling: Schooling, Coaching & Outreach; Cyberinfrastructure & Knowledge Administration; and others to make sure that the Heart is profitable in finishing up a visionary and thriving program.

3.e. Exterior Advisory Committee: Describe plans for an Exterior Advisory Committee, together with the vary of experience and obligations mandatory for its environment friendly and efficient operate, the dimensions of the committee, and a plan for selecting a various set of committee members. Don’t record names of any potential members. Embody an outline of how the Heart will interact with and make the most of the experience of the Exterior Advisory Committee.

4. Finances and Finances Justification Present a price range for every of the seven years. Analysis.gov or Grants.gov will robotically present a cumulative price range. Necessary info for Grants.gov customers: Grants.gov helps proposal budgets for as much as 5 years. After the proposal is submitted to NSF through Grants.gov and efficiently transferred to NSF for processing, Grants.gov candidates ought to use the Proposal File Replace characteristic in Analysis.gov to enter the proposal price range for the sixth and seventh years. The proposed price range ought to be per the wants and complexity of the proposed exercise. Present an in depth price range for every of the seven years, roughly reflecting three phases: Section 1: The Acceleration Section – Years 1 and a pair of (ca 25% of complete award dimension); Section 2: The Regular-State Section – Years 3, 4 and 5 (ca. 60% of the entire award dimension); and Section 3: The Wrap-Up Section – throughout Years 6 and seven (ca. 15% of the entire award dimension). Word that funding for Section 2 and/or Section 3 is contingent upon a profitable website go to throughout Yr 2 and/or 5 (see Particular Award Circumstances). The price range ought to embody funds for journey for no less than two PIs/coPIs, one key senior personnel and one pupil/trainee to attend every PI assembly in the course of the lifetime of the challenge, in years 2, 5, and seven.

5. Amenities, Gear and Different Assets Present a synopsis of organizational assets that shall be obtainable to the Heart (devoted area, entry to amenities and instrumentation, college and employees positions, entry to packages that help with curriculum improvement or broadening participation, or different organizational packages that would present help to the Heart). To ensure that NSF to evaluate the scope of a proposed challenge, all assets (together with these from collaborating organizations) obtainable to the challenge, should be described on this part. Word that inclusion of voluntary dedicated value sharing is prohibited. The outline ought to be narrative in nature and should not embody any quantifiable monetary info.

6. Particular Data and Required Supplementary Paperwork

Senior Personnel Record Spreadsheet: An extra spreadsheet itemizing all PIs, CoPIs and different senior personnel concerned within the challenge should be submitted. This spreadsheet is separate from the spreadsheet that lists collaborators and different affiliations (COA) info. The spreadsheet template may be discovered at https://www.nsf.gov/bio/dbi/dbipersonnellist.xlsx. Please learn the directions fastidiously. Utilizing the template, compile an Excel file that gives info for all individuals recognized within the proposal as: “PI or co-PI” (i.e., these listed on the Cowl Sheet); “Different Senior Personnel/Subawardee”; or “Different Personnel” who’ve a biographical sketch included within the proposal, together with worldwide collaborators (if relevant). Just one spreadsheet ought to be submitted per challenge. The file should embody the NSF proposal ID assigned after submission of your proposal (i.e., not the Short-term ID # or Grants.gov ID #). As soon as accomplished, the file ought to be submitted by e-mail to [email protected] inside one enterprise day of the total proposal submission.

Outcomes of Prior NSF Assist (As much as one web page). This supplementary doc could also be used to report Outcomes of Prior NSF Assist as required within the PAPPG if relevant to any PI or co-PI per the PAPPG and never addressed in Mission Description. This doc may additionally comprise outcomes of help from different funding companies listed on this solicitation following the identical content material tips as given for the NSF requirement.

Ethics Plan (required, as much as one web page). Present a transparent assertion of the proposed Heart’s insurance policies on ethics coaching, accountable conduct of analysis, and mental property rights. Dialogue ought to tackle the character of the analysis, methodologies used, possession of analysis and concepts, and roles and obligations relating to mental property. A program of coaching in ethics and accountable conduct of analysis throughout the cross-disciplinary and multi-organizational context of the Heart, for all Heart and subawardee employees, together with college, visiting college, industrial fellows, postdoctoral researchers, and graduate and undergraduate college students is required. Coaching matters ought to embody the character of the analysis, methodologies used, possession of analysis and concepts, and roles and obligations relating to mental property. Proposers are inspired to deal with the connection between the Heart’s ethics plan and the broader consideration of ethics in pandemic analysis, particularly in human methods. This plan doesn’t supplant any IRB requirement arising from the proposed challenge (see PAPPG).

Knowledge Administration Plan (required, as much as two pages). The PAPPG requires the inclusion of a Knowledge Administration Plan (DMP) with all full proposal submissions. The DMP may be now not than two pages and should be inclusive of your entire challenge. All tasks should adhere to FAIR (Findable, Accessible, Interoperable, and Reusable) practices, and be sure that knowledge, organic supplies and/or different assets are collected, archived, digitized, and made obtainable utilizing strategies that permit present and future investigators to entry knowledge and materials. Funded tasks should disseminate challenge knowledge broadly in a well timed and accountable method, utilizing extensively accepted digital knowledge requirements, a named community-accepted, publicly-accessible knowledge repository with as few restrictions as attainable. Knowledge and digital merchandise ought to be recognized, and the next described for every of them:


Format and customary of major knowledge;
Metadata to be collected and disseminated with the first knowledge;
Timetable of launch of ALL knowledge, per privateness and different issues relating to delicate info;
Repository for use;
License to be used, with an emphasis on open supply licenses;
Technique for knowledge attribution, curation, storage, sharing, and authentication;
Any constraints on launch, which should be clearly justified; and
Particular person(s) liable for the discharge.

All software program and code should be in a versioned code repository. The PIPP initiative strongly encourages launch of ready-to-use software program and code by means of integration with computing assets. Revealed outcomes ought to all the time embody info on the right way to entry the supporting knowledge.

Postdoctoral Researcher Mentoring Plan (as relevant). Along with the overall parts of the postdoctoral mentoring plan described within the PAPPG, tackle how the actions of the Heart will particularly improve the skilled improvement of postdoctoral researchers (e.g., by advantage of entry to a number of tasks and organizations comprising the Heart).

Letters of Collaboration (as relevant). Letters ought to doc collaborative preparations of significance to the proposal and MUST keep throughout the PAPPG requirement to state solely the intent to collaborate. They need to not comprise endorsements or analysis of the proposed challenge. Letters of Collaboration shall be supplied within the Supplementary Paperwork part of the proposal and may observe the format directions specified within the NSF PAPPG. Word that letters of collaboration are usually not mandatory for subawardee organizations, whose dedication is express within the proposal.

Letter of Dedication (required, as much as one web page). A letter of dedication from the Dean or equal on the lead establishment should be submitted as a part of the proposal given the broad focus of the Facilities. The letter ought to verify the establishment’s help of school involvement within the Heart in addition to the present assets, as described within the challenge description and/or amenities doc, and that these assets shall be obtainable to the Heart for its lifespan.

Mental Contribution and Credit score Plan (required, as much as one web page): Present a transparent plan for the administration of the rights of and credit score to challenge individuals associated to analysis merchandise, together with however not restricted to: knowledge, instruments, strategies, code, fashions, manuscript authorship, and different mental contributions. This part ought to complement, fairly than overlap with, the Knowledge Administration Plan and clarify how the challenge individuals will collaboratively guarantee a good and equitable project of credit score to all challenge individuals primarily based on agreed-upon standards of contribution. As a result of totally different sub-disciplines and disciplines can have vastly totally different expectations associated to credit score, the proposers must doc how they’ll tackle these necessary insurance policies, associated to all challenge individuals, particularly early-career researchers.

7. Single Copy Paperwork Non-obligatory: Record of steered reviewers or reviewers to not embody (with a quick rationalization or justification for why the reviewer ought to be excluded).

B. Budgetary Data

Value Sharing:

Inclusion of voluntary dedicated value sharing is prohibited.

Finances Preparation Directions:

Proposal budgets ought to embody funds for journey for no less than two PIs/coPIs, one key senior personnel and one pupil/trainee to attend every PI assembly in the course of the lifetime of the challenge, in years 2, 5, and seven.

Necessary info for Grants.gov customers: Grants.gov helps proposal budgets for as much as 5 years. After the proposal is submitted to NSF through Grants.gov and efficiently transferred to NSF for processing, Grants.gov candidates ought to use the Proposal File Replace characteristic in Analysis.gov to enter the proposal price range for the sixth and seventh years.

C. Due Dates

Letter of Intent Due Date(s) (required) (due by 5 p.m. submitter’s native time):

     August 25, 2023

Full Proposal Deadline(s) (due by 5 p.m. submitter’s native time):

     December 08, 2023

D. Analysis.gov/Grants.gov Necessities

For Proposals Submitted By way of Analysis.gov:

To arrange and submit a proposal through Analysis.gov, see detailed technical directions obtainable at: https://www.analysis.gov/research-portal/appmanager/base/desktop?_nfpb=true&_pageLabel=research_node_display&_nodePath=/researchGov/Service/Desktop/ProposalPreparationandSubmission.html. For Analysis.gov consumer help, name the Analysis.gov Assist Desk at 1-800-673-6188 or e-mail [email protected]. The Analysis.gov Assist Desk solutions common technical questions associated to the usage of the Analysis.gov system. Particular questions associated to this program solicitation ought to be referred to the NSF program employees contact(s) listed in Part VIII of this funding alternative.

For Proposals Submitted By way of Grants.gov:

Earlier than utilizing Grants.gov for the primary time, every group should register to create an institutional profile. As soon as registered, the applicant’s group can then apply for any federal grant on the Grants.gov web site. Complete details about utilizing Grants.gov is accessible on the Grants.gov Applicant Assets webpage: https://www.grants.gov/net/grants/candidates.html. As well as, the NSF Grants.gov Software Information (see hyperlink in Part V.A) offers directions relating to the technical preparation of proposals through Grants.gov. For Grants.gov consumer help, contact the Grants.gov Contact Heart at 1-800-518-4726 or by e-mail: [email protected]. The Grants.gov Contact Heart solutions common technical questions associated to the usage of Grants.gov. Particular questions associated to this program solicitation ought to be referred to the NSF program employees contact(s) listed in Part VIII of this solicitation.

Submitting the Proposal: As soon as all paperwork have been accomplished, the Approved Organizational Consultant (AOR) should submit the applying to Grants.gov and confirm the specified funding alternative and company to which the applying is submitted. The AOR should then signal and submit the applying to Grants.gov. The finished software shall be transferred to Analysis.gov for additional processing.

Proposers that submitted through Analysis.gov could use Analysis.gov to confirm the standing of their submission to NSF. For proposers that submitted through Grants.gov, till an software has been acquired and validated by NSF, the Approved Organizational Consultant could verify the standing of an software on Grants.gov. After proposers have acquired an e-mail notification from NSF, Analysis.gov ought to be used to verify the standing of an software.

VI. NSF PROPOSAL PROCESSING AND REVIEW PROCEDURES

Proposals acquired by NSF are assigned to the suitable NSF program for acknowledgement and, in the event that they meet NSF necessities, for overview. All proposals are fastidiously reviewed by a scientist, engineer, or educator serving as an NSF Program Officer, and often by three to 10 different individuals exterior NSF both as advert hoc reviewers, panelists, or each, who’re consultants within the explicit fields represented by the proposal. These reviewers are chosen by Program Officers charged with oversight of the overview course of. Proposers are invited to counsel names of individuals they consider are particularly effectively certified to overview the proposal and/or individuals they would favor not overview the proposal. These strategies could function one supply within the reviewer choice course of on the Program Officer’s discretion. Submission of such names, nonetheless, is non-obligatory. Care is taken to make sure that reviewers haven’t any conflicts of curiosity with the proposal. As well as, Program Officers could get hold of feedback from website visits earlier than recommending remaining motion on proposals. Senior NSF employees additional overview suggestions for awards. A flowchart that depicts your entire NSF proposal and award course of (and related timeline) is included in PAPPG Exhibit III-1.

A complete description of the Basis’s benefit overview course of is accessible on the NSF web site at: https://www.nsf.gov/bfa/dias/coverage/merit_review/.

Proposers must also concentrate on core methods which can be important to the achievement of NSF’s mission, as articulated in Main the World in Discovery and Innovation, STEM Expertise Growth and the Supply of Advantages from Analysis – NSF Strategic Plan for Fiscal Years (FY) 2022 – 2026. These methods are built-in in this system planning and implementation course of, of which proposal overview is one half. NSF’s mission is especially well-implemented by means of the mixing of analysis and training and broadening participation in NSF packages, tasks, and actions.

One of many strategic aims in help of NSF’s mission is to foster integration of analysis and training by means of the packages, tasks, and actions it helps at educational and analysis establishments. These establishments should recruit, prepare, and put together a various STEM workforce to advance the frontiers of science and take part within the U.S. technology-based financial system. NSF’s contribution to the nationwide innovation ecosystem is to supply cutting-edge analysis beneath the steerage of the Nation’s most artistic scientists and engineers. NSF additionally helps improvement of a robust science, know-how, engineering, and arithmetic (STEM) workforce by investing in constructing the information that informs enhancements in STEM instructing and studying.

NSF’s mission requires the broadening of alternatives and increasing participation of teams, establishments, and geographic areas which can be underrepresented in STEM disciplines, which is important to the well being and vitality of science and engineering. NSF is dedicated to this precept of range and deems it central to the packages, tasks, and actions it considers and helps.

A. Benefit Evaluation Rules and Standards

The Nationwide Science Basis strives to spend money on a strong and numerous portfolio of tasks that creates new information and allows breakthroughs in understanding throughout all areas of science and engineering analysis and training. To determine which tasks to help, NSF depends on a benefit overview course of that comes with consideration of each the technical elements of a proposed challenge and its potential to contribute extra broadly to advancing NSF’s mission “to advertise the progress of science; to advance the nationwide well being, prosperity, and welfare; to safe the nationwide protection; and for different functions.” NSF makes each effort to conduct a good, aggressive, clear benefit overview course of for the collection of tasks.

1. Benefit Evaluation Rules

These ideas are to be given due diligence by PIs and organizations when making ready proposals and managing tasks, by reviewers when studying and evaluating proposals, and by NSF program employees when figuring out whether or not or to not advocate proposals for funding and whereas overseeing awards. On condition that NSF is the first federal company charged with nurturing and supporting excellence in primary analysis and training, the next three ideas apply:

All NSF tasks ought to be of the very best high quality and have the potential to advance, if not rework, the frontiers of information.
NSF tasks, within the mixture, ought to contribute extra broadly to reaching societal objectives. These “Broader Impacts” could also be completed by means of the analysis itself, by means of actions which can be instantly associated to particular analysis tasks, or by means of actions which can be supported by, however are complementary to, the challenge. The challenge actions could also be primarily based on beforehand established and/or revolutionary strategies and approaches, however in both case should be effectively justified.
Significant evaluation and analysis of NSF funded tasks ought to be primarily based on applicable metrics, preserving in thoughts the probably correlation between the impact of broader impacts and the assets supplied to implement tasks. If the dimensions of the exercise is restricted, analysis of that exercise in isolation will not be more likely to be significant. Thus, assessing the effectiveness of those actions could greatest be achieved at the next, extra aggregated, stage than the person challenge.

With respect to the third precept, even when evaluation of Broader Impacts outcomes for explicit tasks is finished at an aggregated stage, PIs are anticipated to be accountable for finishing up the actions described within the funded challenge. Thus, particular person tasks ought to embody clearly acknowledged objectives, particular descriptions of the actions that the PI intends to do, and a plan in place to doc the outputs of these actions.

These three benefit overview ideas present the idea for the benefit overview standards, in addition to a context inside which the customers of the standards can higher perceive their intent.

2. Benefit Evaluation Standards

All NSF proposals are evaluated by means of use of the 2 Nationwide Science Board permitted benefit overview standards. In some situations, nonetheless, NSF will make use of extra standards as required to spotlight the particular aims of sure packages and actions.

The 2 benefit overview standards are listed under. Each standards are to be given full consideration in the course of the overview and decision-making processes; every criterion is important however neither, by itself, is enough. Subsequently, proposers should absolutely tackle each standards. (PAPPG Chapter II.D.2.d(i). incorporates extra info to be used by proposers in improvement of the Mission Description part of the proposal). Reviewers are strongly inspired to overview the standards, together with PAPPG Chapter II.D.2.d(i), previous to the overview of a proposal.

When evaluating NSF proposals, reviewers shall be requested to contemplate what the proposers need to do, why they need to do it, how they plan to do it, how they’ll know in the event that they succeed, and what advantages may accrue if the challenge is profitable. These points apply each to the technical elements of the proposal and the best way through which the challenge could make broader contributions. To that finish, reviewers shall be requested to judge all proposals towards two standards:

Mental Benefit: The Mental Benefit criterion encompasses the potential to advance information; and
Broader Impacts: The Broader Impacts criterion encompasses the potential to learn society and contribute to the achievement of particular, desired societal outcomes.

The next parts ought to be thought-about within the overview for each standards:

What’s the potential for the proposed exercise to
Advance information and understanding inside its personal discipline or throughout totally different fields (Mental Benefit); and
Profit society or advance desired societal outcomes (Broader Impacts)?

To what extent do the proposed actions counsel and discover artistic, authentic, or probably transformative ideas?
Is the plan for finishing up the proposed actions well-reasoned, well-organized, and primarily based on a sound rationale? Does the plan incorporate a mechanism to evaluate success?
How effectively certified is the person, staff, or group to conduct the proposed actions?
Are there satisfactory assets obtainable to the PI (both on the residence group or by means of collaborations) to hold out the proposed actions?

Broader impacts could also be completed by means of the analysis itself, by means of the actions which can be instantly associated to particular analysis tasks, or by means of actions which can be supported by, however are complementary to, the challenge. NSF values the development of scientific information and actions that contribute to achievement of societally related outcomes. Such outcomes embody, however are usually not restricted to: full participation of ladies, individuals with disabilities, and different underrepresented teams in science, know-how, engineering, and arithmetic (STEM); improved STEM training and educator improvement at any stage; elevated public scientific literacy and public engagement with science and know-how; improved well-being of people in society; improvement of a various, globally aggressive STEM workforce; elevated partnerships between academia, trade, and others; improved nationwide safety; elevated financial competitiveness of the USA; and enhanced infrastructure for analysis and training.

Proposers are reminded that reviewers can even be requested to overview the Knowledge Administration Plan and the Postdoctoral Researcher Mentoring Plan, as applicable.

Further Solicitation Particular Evaluation Standards

Along with the Nationwide Science Board benefit overview standards, reviewers shall be requested to use the next standards when reviewing proposals submitted to this solicitation:

Foundational analysis and improvement actions: How effectively does the proposed Heart contribute new information or strategies towards predictive intelligence for pandemic prevention?
Use-inspired insights to important issues: How effectively does the proposed Heart leverage the use-inspired analysis context to supply insights to important issues referring to predictive intelligence for pandemic prevention that speed up translation of analysis outcomes to follow.
Strategic impression: What’s the potential for the Heart to make a long-lasting strategic impression past its analysis outcomes? Particularly:


How will the proposed Heart actively nurture and develop the subsequent era of expertise?
To what extent is the proposed Heart comprised of a multidisciplinary group of scientists, engineers, practitioners and/or educators applicable to the challenge?
How effectively does the proposed Heart leverage a number of organizations to create vital new analysis capabilities in new Facilities of pandemic preparedness and management and create a community for broadening participation from teams underrepresented in STEM to encourage participation of the total spectrum of numerous expertise that society has to supply and numerous establishments?
How effectively does the proposal exhibit plans to function as a nexus level for collaborative efforts for analysis throughout a multitude of science and engineering fields, and engages externally so as to add to a various Heart that’s extra than simply the sum of the elements?

B. Evaluation and Choice Course of

Proposals submitted in response to this program solicitation shall be reviewed by Advert hoc Evaluation and/or Panel Evaluation, or Reverse Web site Evaluation.

A two-stage overview course of shall be used for proposals submitted to this program.

Full Proposal Evaluation Course of: Full proposals shall be reviewed by a Evaluation Panel augmented as mandatory with advert hoc evaluations.

Reverse Web site Go to: Some proposals shall be chosen for a reverse website go to previous to remaining collection of the awarded Heart.

Reviewers shall be requested to judge proposals utilizing two Nationwide Science Board permitted benefit overview standards and, if relevant, extra program particular standards. A abstract ranking and accompanying narrative will typically be accomplished and submitted by every reviewer and/or panel. The Program Officer assigned to handle the proposal’s overview will take into account the recommendation of reviewers and can formulate a advice.

After scientific, technical and programmatic overview and consideration of applicable elements, the NSF Program Officer recommends to the cognizant Division Director whether or not the proposal ought to be declined or advisable for award. NSF strives to have the ability to inform candidates whether or not their proposals have been declined or advisable for funding inside six months. Giant or significantly advanced proposals or proposals from new awardees could require extra overview and processing time. The time interval begins on the deadline or goal date, or receipt date, whichever is later. The interval ends when the Division Director acts upon the Program Officer’s advice.

After programmatic approval has been obtained, the proposals advisable for funding shall be forwarded to the Division of Grants and Agreements or the Division of Acquisition and Cooperative Assist for overview of enterprise, monetary, and coverage implications. After an administrative overview has occurred, Grants and Agreements Officers carry out the processing and issuance of a grant or different settlement. Proposers are cautioned that solely a Grants and Agreements Officer could make commitments, obligations or awards on behalf of NSF or authorize the expenditure of funds. No dedication on the a part of NSF ought to be inferred from technical or budgetary discussions with a NSF Program Officer. A Principal Investigator or group that makes monetary or personnel commitments within the absence of a grant or cooperative settlement signed by the NSF Grants and Agreements Officer does so at their very own threat.

As soon as an award or declination determination has been made, Principal Investigators are supplied suggestions about their proposals. In all circumstances, evaluations are handled as confidential paperwork. Verbatim copies of evaluations, excluding the names of the reviewers or any reviewer-identifying info, are despatched to the Principal Investigator/Mission Director by the Program Officer. As well as, the proposer will obtain an evidence of the choice to award or decline funding.

VII. AWARD ADMINISTRATION INFORMATION

A. Notification of the Award

Notification of the award is made to the submitting group by an NSF Grants and Agreements Officer. Organizations whose proposals are declined shall be suggested as promptly as attainable by the cognizant NSF Program administering this system. Verbatim copies of evaluations, not together with the id of the reviewer, shall be supplied robotically to the Principal Investigator. (See Part VI.B. for added info on the overview course of.)

B. Award Circumstances

An NSF award consists of: (1) the award discover, which incorporates any particular provisions relevant to the award and any numbered amendments thereto; (2) the price range, which signifies the quantities, by classes of expense, on which NSF has primarily based its help (or in any other case communicates any particular approvals or disapprovals of proposed expenditures); (3) the proposal referenced within the award discover; (4) the relevant award circumstances, resembling Grant Normal Circumstances (GC-1)*; or Analysis Phrases and Circumstances* and (5) any announcement or different NSF issuance which may be integrated by reference within the award discover. Cooperative agreements are also administered in accordance with NSF Cooperative Settlement Monetary and Administrative Phrases and Circumstances (CA-FATC) and the relevant Programmatic Phrases and Circumstances. NSF awards are electronically signed by an NSF Grants and Agreements Officer and transmitted electronically to the group through e-mail.

*These paperwork could also be accessed electronically on NSF’s Web site at https://www.nsf.gov/awards/managing/award_conditions.jsp?org=NSF. Paper copies could also be obtained from the NSF Publications Clearinghouse, phone (703) 292-8134 or by e-mail from [email protected].

Extra complete info on NSF Award Circumstances and different necessary info on the administration of NSF awards is contained within the NSF Proposal & Award Insurance policies & Procedures Information (PAPPG) Chapter VII, obtainable electronically on the NSF Web site at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.

Administrative and Nationwide Coverage Necessities

Construct America, Purchase America

As expressed in Govt Order 14005, Making certain the Future is Made in All of America by All of America’s Employees (86 FR 7475), it’s the coverage of the manager department to make use of phrases and circumstances of Federal monetary help awards to maximise, per legislation, the usage of items, merchandise, and supplies produced in, and providers supplied in, the USA.

In keeping with the necessities of the Construct America, Purchase America Act (Pub. L. 117-58, Division G, Title IX, Subtitle A, November 15, 2021), no funding made obtainable by means of this funding alternative could also be obligated for an award until all iron, metal, manufactured merchandise, and development supplies used within the challenge are produced in the USA. For added info, go to NSF’s Construct America, Purchase America webpage.

Particular Award Circumstances:

Twin Use Analysis of Concern and enhanced PPP: If a choice is made to fund a proposal, the place the usage of a choose agent (however not an enhanced PPP) as recognized by the Coverage is proposed, the proposer should submit proof of registration of the choose agent with the CDC or USDA as required by the Choose Agent Laws and the proposer should submit a justification from the Institutional Evaluation Entity (IRE) demonstrating how the potential advantages of the analysis utilizing the choose agent far outweigh the dangers. If a choice is made to fund a proposal utilizing or probably leading to enhanced PPP, the proposer should submit a justification from the IRE demonstrating advantages outweigh the dangers, however registration with CDC or USDA will not be required.

Within the uncommon circumstances the place NSF funds analysis that includes the creation, switch, or use of enhanced potential pandemic pathogens, then particular award circumstances shall be utilized to make sure satisfactory oversight by the cognizant NSF program officer or different NSF official. Award phrases and circumstances additionally will specify the institution of a threat mitigation plan for the analysis that should be reviewed and permitted by the IRE and NSF, in addition to the requirement of upkeep of data of institutional overview of the analysis and threat mitigation actions for 3 years after completion of the challenge. Different particular award phrases and circumstances could also be utilized to make sure compliance with U.S. coverage and mitigate the potential for misuse of outcomes of NSF funded analysis.

Web site Visits and Launch of Funds: PIPP Section II Heart awards are made within the type of cooperative agreements. The cooperative settlement can have an intensive part of Particular Circumstances referring to the interval of efficiency, assertion of labor, awardee obligations, NSF obligations, joint NSF-awardee obligations, funding and funding schedule, reporting necessities, key personnel, and different circumstances. NSF has duty for offering common oversight and monitoring of Facilities to assist guarantee efficient efficiency and administration and different actions essential to additional the aims of this system.

Assist for every year of the cooperative settlement of the awarded Heart shall be contingent upon a passable annual overview of the Heart’s progress and future plans, with an emphasis on the standard and impression of the synthesis actions, training, and broadening participation. All funding is topic to availability. It’s anticipated that every PIPP Section II Heart challenge shall be benefit reviewed in two website visits (or reverse website visits) carried out throughout Yr 2 and Yr 5. The analysis throughout Yr 2 will assess challenge progress and decide if the challenge warrants continued help in Years 3 by means of 5. The analysis throughout yr 5 will assess the challenge progress and decide if the challenge warrants help for Years 6 and seven. If deemed mandatory, NSF could conduct extra website visits and/or reverse website visits as a part of annual overview of Heart efficiency. These visits shall be led by cognizant company employees and will embody a panel of exterior evaluators.

Acknowledgement of Assist: Awardees shall be required to incorporate applicable acknowledgment of NSF and associate help in experiences and/or publications on work carried out beneath an award. An instance of such an acknowledgement can be: “This materials relies upon work supported by the PIPP Section II Heart Program supported by NSF beneath Award Title and No. [Recipient enters project title and awards number(s)].”

TBD – Programmatic Phrases and Circumstances:

Programmatic Phrases and Circumstances could also be utilized primarily based on the particular Heart design, deliberate actions, or findings from the Benefit Evaluation course of.

C. Reporting Necessities

For all multi-year grants (together with each customary and persevering with grants), the Principal Investigator should submit an annual challenge report back to the cognizant Program Officer no later than 90 days previous to the top of the present price range interval. (Some packages or awards require submission of extra frequent challenge experiences). No later than 120 days following expiration of a grant, the PI is also required to submit a remaining challenge report, and a challenge outcomes report for most of the people.

Failure to supply the required annual or remaining challenge experiences, or the challenge outcomes report, will delay NSF overview and processing of any future funding increments in addition to any pending proposals for all recognized PIs and co-PIs on a given award. PIs ought to study the codecs of the required experiences upfront to guarantee availability of required knowledge.

PIs are required to make use of NSF’s digital project-reporting system, obtainable by means of Analysis.gov, for preparation and submission of annual and remaining challenge experiences. Such experiences present info on accomplishments, challenge individuals (particular person and organizational), publications, and different particular merchandise and impacts of the challenge. Submission of the report through Analysis.gov constitutes certification by the PI that the contents of the report are correct and full. The challenge outcomes report additionally should be ready and submitted utilizing Analysis.gov. This report serves as a quick abstract, ready particularly for the general public, of the character and outcomes of the challenge. This report shall be posted on the NSF web site precisely as it’s submitted by the PI.

Extra complete info on NSF Reporting Necessities and different necessary info on the administration of NSF awards is contained within the NSF Proposal & Award Insurance policies & Procedures Information (PAPPG) Chapter VII, obtainable electronically on the NSF Web site at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg.

As well as, PIPP Section II awardees should:

Produce one challenge consequence “highlights” yearly for Years 4 by means of 7 that’s ready for a lay viewers; these highlights shall be utilized in NSF reporting and outreach;
Create and preserve an energetic challenge site that shares details about the challenge; and
Attend three PI conferences to share details about the challenge (please make provisions for journey for no less than two PIs/coPI, one senior personnel and one pupil/trainee to attend every PI assembly in the course of the lifetime of the challenge, in years 2, 5, and seven).

Further reporting necessities could also be required as a part of the award phrases and circumstances of particular person awards.

VIII. AGENCY CONTACTS

Please word that this system contact info is present on the time of publishing. See program web site for any updates to the factors of contact.

Normal inquiries relating to this program ought to be made to:

Katharina Dittmar, phone: (703) 292-7799, e-mail: [email protected]
Mitra Basu, phone: (703) 292-8649, e-mail: [email protected]
Goli Yamini, phone: (703) 292-8910, e-mail: [email protected]
Rebecca Ferrell, phone: (703) 292-7850, e-mail: [email protected]
Zhilan J. Feng, phone: (703) 292-7523, e-mail: [email protected]
Daniel McAdams, phone: (703) 292-4654, e-mail: [email protected]
Joanna Shisler, phone: (703) 292-5368, e-mail: [email protected]
Joseph M. Whitmeyer, phone: (703) 292-7808, e-mail: [email protected]
Catalina Achim, phone: (703) 292-2048, e-mail: [email protected]

For questions associated to the usage of NSF methods contact:

NSF Assist Desk: 1-800-673-6188
Analysis.gov Assist Desk e-mail: [email protected]

For questions referring to Grants.gov contact:

Grants.gov Contact Heart: If the Approved Organizational Representatives (AOR) has not acquired a affirmation message from Grants.gov inside 48 hours of submission of software, please contact through phone: 1-800-518-4726; e-mail: [email protected].

PIs ought to ship inquiries to [email protected] instead of contacting particular person program administrators.

IX. OTHER INFORMATION

The NSF web site offers essentially the most complete supply of data on NSF Directorates (together with contact info), packages and funding alternatives. Use of this web site by potential proposers is strongly inspired. As well as, “NSF Replace” is an information-delivery system designed to maintain potential proposers and different events apprised of recent NSF funding alternatives and publications, necessary adjustments in proposal and award insurance policies and procedures, and upcoming NSF Grants Conferences. Subscribers are knowledgeable by means of e-mail or the consumer’s Internet browser every time new publications are issued that match their recognized pursuits. “NSF Replace” additionally is accessible on NSF’s web site.

Grants.gov offers an extra digital functionality to seek for Federal government-wide grant alternatives. NSF funding alternatives could also be accessed through this mechanism. Additional info on Grants.gov could also be obtained at https://www.grants.gov.

ABOUT THE NATIONAL SCIENCE FOUNDATION

The Nationwide Science Basis (NSF) is an impartial Federal company created by the Nationwide Science Basis Act of 1950, as amended (42 USC 1861-75). The Act states the aim of the NSF is “to advertise the progress of science; [and] to advance the nationwide well being, prosperity, and welfare by supporting analysis and training in all fields of science and engineering.”

NSF funds analysis and training in most fields of science and engineering. It does this by means of grants and cooperative agreements to greater than 2,000 faculties, universities, Ok-12 college methods, companies, casual science organizations and different analysis organizations all through the US. The Basis accounts for about one-fourth of Federal help to educational establishments for primary analysis.

NSF receives roughly 55,000 proposals every year for analysis, training and coaching tasks, of which roughly 11,000 are funded. As well as, the Basis receives a number of thousand purposes for graduate and postdoctoral fellowships. The company operates no laboratories itself however does help Nationwide Analysis Facilities, consumer amenities, sure oceanographic vessels and Arctic and Antarctic analysis stations. The Basis additionally helps cooperative analysis between universities and trade, US participation in worldwide scientific and engineering efforts, and academic actions at each educational stage.

Facilitation Awards for Scientists and Engineers with Disabilities (FASED) present funding for particular help or tools to allow individuals with disabilities to work on NSF-supported tasks. See the NSF Proposal & Award Insurance policies & Procedures Information Chapter II.F.7 for directions relating to preparation of most of these proposals.

The Nationwide Science Basis has Telephonic Machine for the Deaf (TDD) and Federal Data Relay Service (FIRS) capabilities that allow people with listening to impairments to speak with the Basis about NSF packages, employment or common info. TDD could also be accessed at (703) 292-5090 and (800) 281-8749, FIRS at (800) 877-8339.

The Nationwide Science Basis Data Heart could also be reached at (703) 292-5111.

The Nationwide Science Basis promotes and advances scientific progress in the USA by competitively awarding grants and cooperative agreements for analysis and training within the sciences, arithmetic, and engineering.

To get the most recent details about program deadlines, to obtain copies of NSF publications, and to entry abstracts of awards, go to the NSF Web site at https://www.nsf.gov

2415 Eisenhower Avenue, Alexandria, VA 22314

For Normal Data(NSF Data Heart):

(703) 292-5111

TDD (for the hearing-impaired):

(703) 292-5090

To Order Publications or Types:


 

Ship an e-mail to:

[email protected]

or phone:

(703) 292-8134

(703) 292-5111

PRIVACY ACT AND PUBLIC BURDEN STATEMENTS

The knowledge requested on proposal kinds and challenge experiences is solicited beneath the authority of the Nationwide Science Basis Act of 1950, as amended. The knowledge on proposal kinds shall be utilized in reference to the collection of certified proposals; and challenge experiences submitted by awardees shall be used for program analysis and reporting throughout the Govt Department and to Congress. The knowledge requested could also be disclosed to certified reviewers and employees assistants as a part of the proposal overview course of; to proposer establishments/grantees to supply or get hold of knowledge relating to the proposal overview course of, award choices, or the administration of awards; to authorities contractors, consultants, volunteers and researchers and educators as mandatory to finish assigned work; to different authorities companies or different entities needing info relating to candidates or nominees as a part of a joint software overview course of, or in an effort to coordinate packages or coverage; and to a different Federal company, courtroom, or occasion in a courtroom or Federal administrative continuing if the federal government is a celebration. Details about Principal Investigators could also be added to the Reviewer file and used to pick potential candidates to function peer reviewers or advisory committee members. See System of Document Notices, NSF-50, “Principal Investigator/Proposal File and Related Information,” and NSF-51, “Reviewer/Proposal File and Related Information.” Submission of the knowledge is voluntary. Failure to supply full and full info, nonetheless, could scale back the opportunity of receiving an award.

An company could not conduct or sponsor, and an individual will not be required to answer, an info assortment until it shows a sound Workplace of Administration and Finances (OMB) management quantity. The OMB management quantity for this assortment is 3145-0058. Public reporting burden for this assortment of data is estimated to common 120 hours per response, together with the time for reviewing directions. Ship feedback relating to the burden estimate and some other facet of this assortment of data, together with strategies for lowering this burden, to:

Suzanne H. Plimpton
Studies Clearance Officer
Coverage Workplace, Division of Establishment and Award Assist
Workplace of Finances, Finance, and Award Administration
Nationwide Science Basis
Alexandria, VA 22314